Human leukocyte antigen is better than serological screening for celiac diseases in rheumatological arthritis.

The major histocompatibility complex (MHC) is located on chromosome 6 and includes more than 200 genes, most of which such as those encoding HLA are a mandatory requisite for the immune system. In particular, the HLA class II genomic region encodes proteins (namely HLA DR, DQ, and DP) involved in the presentation of extracellular peptides to HLA class II T helper cells (Thelper) that mediates the adaptive immunity; thus, this region is frequently associated with autoimmune disorders (2).